Fri May 16 2025

81 articles - From Friday May 09 2025 to Friday May 16 2025

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol

Effectiveness of six international guidelines using FIB-4 and FibroScan for risk stratification of MASLD in type 2 diabetes.

The percentage of T2D patients in diabetes clinics requiring referral to hepatology (12%) was similar across the six pathways, but higher (19%) when VCTE was used as the first line, with a low false negative rate (3%) for advanced fibrosis.

Pubmed   Journal   ReadQx 

J Hepatol

EASL Clinical Practice Guidelines on extrahepatic abdominal surgery in patients with cirrhosis and advanced chronic liver disease.

These clinical practice guidelines provide comprehensive recommendations for the assessment and perioperative management of patients with cirrhosis undergoing extrahepatic surgery. An individualised patient-centred risk assessment by a multidisciplinary team including hepatologists, surgeons, anaesthesiologists, and other support teams is essential.

Pubmed   Journal   ReadQx 

EASL Clinical Practice Guidelines on the management of autoimmune hepatitis.

The aim of these EASL guidelines is to provide updated guidance on the diagnosis and management of AIH both in adults and children. Updated guidance on the management of patients with variants and specific forms of AIH is also provided, as is detailed guidance on the management of AIH-associated cirrhosis, including surveillance for portal hypertension and hepatocellular carcinoma, as well as liver transplantation in decompensated cirrhosis.

Pubmed   Journal   ReadQx 

EASL Clinical Practice Guidelines on the management of extrahepatic cholangiocarcinoma.

Owing to recent developments and the significant differences in CCA subtypes, EASL commissioned a panel of experts to draft evidence-based recommendations on the management of extrahepatic CCA, comprising distal and perihilar CCA. Particular attention is given to the need for accurate classification systems, the integration of emerging molecular insights, and practical strategies for diagnosis and treatment that reflect real-world clinical scenarios.

Pubmed   Journal   ReadQx 

EASL Clinical Practice Guidelines on the management of hepatitis B virus infection.

The guidelines also discuss emerging biomarkers and evolving definitions of functional and partial cure. Developed through literature review, expert consensus, and a Delphi process, the guidelines aim to equip healthcare providers across disciplines with practical tools to optimise HBV care and outcomes worldwide.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Clin Gastroenterol Hepatol

Medical Therapy for Acute Severe Ulcerative Colitis: A Systematic Review with Meta-analysis.

IFX may be more efficacious than CsA for the treatment of ASUC. Janus kinase inhibitors are promising treatment options in select individuals. Future studies should explore the efficacy of other advanced therapies.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Diabetes Mellitus in Patients With Autoimmune Hepatitis: Frequency, Risk Factors and Effect on Outcome.

New-onset DM occurred in 13% of patients with AIH, was related to older age, non-Caucasian ethnicity, higher prednisolone dose, higher BMI at diagnosis and weight gain; and was an independent predictor of all-cause death/transplantation and of cirrhosis development, underlining the need to minimise steroid burden in AIH.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Association between nonalcoholic fatty liver disease and risk of early onset colorectal cancer.

NAFLD is positively associated with an increased risk of early-onset CRC, particularly in the left colon and rectum. These findings highlight the need for multifaceted preventive strategies, including lifestyle interventions and expanded screening for younger populations with NAFLD.

Pubmed   Journal   ReadQx 

CT-colonography in Fecal Immunochemical Test Positives in a Colorectal Cancer Screening Program.

CTC in FIT-positive screenees was associated with a lower AN detection rate and a higher PCT-CRC rate compared to what is known from colonoscopy. A substantial proportion of complications occurred, and quality reporting was often lacking. This underlines the need for a structured quality assurance program for CTCs performed in FIT-positives. Critical appraisal who to refer for CTC and communication about the benefits and pitfalls of CTC is warranted.

Pubmed   Journal   ReadQx 

Endoscopic Submucosal Dissection for Previously Attempted Colorectal Lesions: An International Multicenter Experience.

Salvage ESD is highly effective in the treatment of PACLs. When performed by experts, AEs were uncommon and mostly managed endoscopically.

Pubmed   Journal   ReadQx 

Liver Transplant is Associated with a Reduced Risk of Colorectal Dysplasia in patients with IBD and concomitant PSC.

Liver transplantation was associated with a reduced risk of colon cancer/dysplasia in patients with PSC-IBD in our cohort.

Pubmed   Journal   ReadQx 

Young adults with metabolic dysfunction-associated steatotic liver disease have an increased risk of early-onset cancer.

Young adults with MASLD, MetALD, or ALD are at increased risk of developing early-onset cancer.

Pubmed   Journal   ReadQx 

Endoscopy

A novel technique for submucosal tumors in esophagus: mucosal zipper endoscopic resection.

MZER seems to provide an optional treatment for proximal or larger esophageal SMTs. The efficacy and safety profiles need further validation through multicenter studies with larger cohorts, given the current limitations of sample size and single-center design.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Combined phosphorus-32 implantation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer: a propensity-score weighted landmark analysis.

In this comparative study between combined chemotherapy and 32 P microparticles implantation with standard chemotherapy for patients with LAPC, the combination showed better survival, disease control and downstaging. The outcomes highlight the need for a randomized controlled trial.

Pubmed   Journal   ReadQx 

Outcomes of Endoscopic Ultrasound-Guided Liver Biopsy Using 22-Gauge vs. 19-Gauge Needles with a Novel Hydrostatic Sampling Technique.

When using the HST, EUS-LB with 22G needles meets adequacy standards at high rates similar to 19G needles. The HST may allow for the use of 22G needles in patients at high risk for adverse events or with challenging anatomies.

Pubmed   Journal   ReadQx 

Gut

Beneficial infections of the enterovirus genus in patients with liver cancer.

Our results suggest that past exposures to members of the Enterovirus genus may be advantageous for cancer patients, highlighting the potential for a viral peptide-based HCC vaccine.

Pubmed   Journal   ReadQx 

Hepatology

GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in hepatocellular carcinoma.

GPD1L is overexpressed in human HCCs and associated with worse clinical outcomes. Aberrant GPD1L expression, driven by ELF1, facilitates conversion of DHAP to G3P conversion to support triacylglycerol synthesis in HCC, promoting tumor growth and metastasis.

Pubmed   Journal   ReadQx 

Hepatic stellate cell heterogeneity: Functional aspects and therapeutic implications.

We explore the spatiotemporal diversity of HSCs, highlighting their subpopulations and their specialized roles, as well as the complex bidirectional communications between HSCs, hepatocytes, endothelial cells, macrophages/monocytes, T cells, and tumor cells. By integrating insights from single-cell sequencing, spatial transcriptomics, preclinical data and clinical data, this review aims to provide an updated understanding of how HSC heterogeneity contributes to liver homeostasis and disease and can be targeted for therapeutic purposes.

Pubmed   Journal   ReadQx 

J Hepatol

Decoding the Resistin-CAP1 Pathway in Intermediate Monocytes Mediating Liver Allograft Rejection.

These findings offer insights into the dynamic changes in the alloimmune microenvironment, pinpointing intermediate monocytes as potential diagnostic and immunotherapeutic targets during allograft rejection. This study holds significant importance in advancing non-invasive diagnostic technologies and immunotherapeutic strategies for allogeneic rejection. Impact and implications This study pioneers the application of spatial transcriptomics in liver transplantation, providing a comprehensive analysis of immune cell spatial distribution, complemented by Souporcell-based chimerism assessment. We demonstrate that intermediate monocytes play a pivotal role in T cell-mediated acute rejection via the Resistin-CAP1 signaling axis. Targeting this pathway using nanogold-siRNA technology effectively mitigates rejection and enhances graft survival. These findings contribute novel insights into the mechanisms of transplant rejection and present promising avenues for the development of targeted therapeutic and diagnostic strategies in liver transplantation.

Pubmed   Journal   ReadQx 

High inherited risk predicts age-associated increases in fibrosis in patients with MASLD.

GRS, PRS-HFC, PRS-5, and PNPLA3 genotypes alone are associated with greater fibrosis per decade, resulting in divergent disease trajectories starting in midlife. Assessing genetic risk in MASLD will identify high-risk patients who require more frequent monitoring. Impact and implications This study provides granular evidence that genetic predisposition, particularly the PNPLA3 G/G genotype, significantly influences the trajectory of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), with a more pronounced impact emerging after the fourth decade of life. These findings highlight the importance of incorporating genetic risk assessment into MASLD management, as it allows for the early identification of high-risk individuals who may benefit from more frequent monitoring and targeted interventions. Given the rising global burden of MASLD, clinicians, researchers, and policymakers should consider integrating genetic stratification into existing risk assessment frameworks to refine screening and surveillance strategies. By optimizing patient selection for non-invasive fibrosis assessment and potential therapeutic interventions, this approach could enhance precision medicine efforts and may improve long-term outcomes.

Pubmed   Journal   ReadQx 

Safety and efficacy of elafibranor in primary sclerosing cholangitis: The ELMWOOD phase II randomized-controlled trial.

Elafibranor was well tolerated in people with PSC and associated with greater biochemical improvements over 12 weeks compared with placebo. A greater magnitude of response was observed with elafibranor 120 mg compared with 80 mg. Impact and implications For people with primary sclerosing cholangitis (PSC), there is a need for a well-tolerated and effective treatment that will enhance quality of life, prevent disease progression, and improve long-term outcomes. Here, we present results from the double-blind period of the phase II ELMWOOD trial in PSC, wherein elafibranor, a peroxisome proliferator-activated receptor-α/δ agonist, demonstrated a favorable safety profile, provided greater biochemical improvements over 12 weeks compared with placebo, and appeared to stabilize markers of fibrosis and improve pruritus. These findings support larger and longer term investigations of elafibranor to explore its therapeutic potential as a treatment for people with PSC.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

Concomitant medications and advanced therapies in ulcerative colitis: patient-centric approach for optimal disease control.

Pubmed   Journal   ReadQx 

Hepatitis D Screening, Testing, and Treatment: Progress Toward Global Elimination Goals.

Pubmed   Journal   ReadQx 

PROLONGED WIRELESS pH MONITORING: HOW LONG IS LONG ENOUGH.

Pubmed   Journal   ReadQx 

The Heated Race Against MASH: Will the Scope, Scalpel, or Medication Prevail?

Pubmed   Journal   ReadQx 

Gastroenterology

Rifaximin Prophylaxis and "Collateral Damage" in Patients with Advanced Liver Disease.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A note from the Editor-in-Chief.

Pubmed   Journal   ReadQx 

Avoiding additional adverse events: exercising caution with use of transpapillary covered metal biliary stents.

Pubmed   Journal   ReadQx 

Endoscopic necrosectomy: A WONderful approach, but when and how often?

Pubmed   Journal   ReadQx 

Endoscopic resection for rectal neuroendocrine tumors: an expanding role.

Pubmed   Journal   ReadQx 

Endoscopy in Inflammatory Bowel Disease: What Every Endoscopist Should Know.

This review underscores the critical role of endoscopy in optimizing patient outcomes through accurate diagnosis, therapeutic precision, and the integration of emerging technologies.

Pubmed   Journal   ReadQx 

J Hepatol

Overcoming drug resistance by harnessing mitochondrial divisome for treating cholangiocarcinoma.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Clin Gastroenterol Hepatol

An unusual complication of EUS-guided trans-gastric liver biopsy.

Pubmed   Journal   ReadQx 

Approach to Difficult Biliary Cannulation.

Pubmed   Journal   ReadQx 

Combined Endoscopic-Thoracoscopic Surgery for Mediastinal Bronchogenic Cyst.

Pubmed   Journal   ReadQx 

EUS-guided treatment of bleeding due to splenic artery pseudoaneurysm.

Pubmed   Journal   ReadQx 

Gastric Adenocarcinoma Presenting as Pulmonary Lymphangitic Carcinomatosis.

Pubmed   Journal   ReadQx 

Incidental Findings During Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis.

Pubmed   Journal   ReadQx 

Langerhans Cell Histiocytosis of the Gastrointestinal Tract.

Pubmed   Journal   ReadQx 

Liver Perforation from a Plastic Biliary Stent.

Pubmed   Journal   ReadQx 

Marked improvement in food impaction biopsy rate (FIBR) after implementation of a multicenter behavioral intervention.

Pubmed   Journal   ReadQx 

Rare Endoscopic Findings of Inverted Esophageal Squamous Cell Carcinoma.

Pubmed   Journal   ReadQx 

Recurrent Erythropoietic protoporphyria post liver transplant.

Pubmed   Journal   ReadQx 

Single Session Combined Endoscopic and Surgical Treatment of Gallstone Ileus.

Pubmed   Journal   ReadQx 

Sustained Clinical Remission in Relapsing IgG4-related Autoimmune Pancreatitis with Dupilumab.

Pubmed   Journal   ReadQx 

The Impact of Age on Disorders of Gut-Brain Interaction.

Pubmed   Journal   ReadQx 

Worsening Racial and Ethnic Disparities in Colorectal Cancer Screening Rates in United States Federally Qualified Health Centers.

Pubmed   Journal   ReadQx 

Endoscopy

A modified variable flip angle release device for endoscopic titanium clips.

Pubmed   Journal   ReadQx 

Digital subtraction imaging with carbon dioxide and liquid contrast in the biliary and pancreatic ducts.

Pubmed   Journal   ReadQx 

Duodenal stricture in Crohn's disease successfully managed with a fully covered metal stent-assisted with double pig-tail stents.

Pubmed   Journal   ReadQx 

Dysphagia and thickened esophageal wall: the application of ultra-slim gastroscope in the diagnosis and treatment of phlegmonous esophagitis.

Pubmed   Journal   ReadQx 

Endoscopic submucosal dissection for removal of a large hypopharyngeal lipoma with oval forceps traction.

Pubmed   Journal   ReadQx 

Experience in endoscopic resection of a mediastinal bronchogenic cyst penetrating the pleura into the thoracic cavity: first reported case.

Pubmed   Journal   ReadQx 

Forward-viewing echoendoscope-guided pancreaticojejunostomy for post-pancreaticoduodenectomy stricture.

Pubmed   Journal   ReadQx 

Management of bleeding from a left-sided epiphrenic esophageal diverticulum: role of positional adjustment in clot removal.

Pubmed   Journal   ReadQx 

Pancreatic carcinoma in situ with focal pancreatic parenchymal atrophy diagnosis using serial pancreatic juice aspiration cytological examination via the minor papilla.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A duodenal spindle cell lipoma removed by endoscopic resection.

Pubmed   Journal   ReadQx 

Elongated duodenal spindle cell lipoma.

Pubmed   Journal   ReadQx 

Manifestations and Endoscopic Treatment of Eosinophilic Esophageal Myositis (with video).

Pubmed   Journal   ReadQx 

Top Tips: ERCP in Patients with Post-Surgical Anatomy.

Pubmed   Journal   ReadQx 

Top tips for diagnosis and surveillance of gastric intestinal metaplasia.

Pubmed   Journal   ReadQx 

Hepatology

Early burden, enduring risk: The alarming outcomes of pediatric MASLD.

Pubmed   Journal   ReadQx 

Hepatology Highlights.

Pubmed   Journal   ReadQx 

Intrahepatic Cholangiocarcinoma PANoptosidy.

Pubmed   Journal   ReadQx 

Letter to the editor: How to count from 0 to 4 without skipping a number.

Pubmed   Journal   ReadQx 

Letter to the editor: Survival benefit of transarterial chemoembolization combined with tyrosine kinase and immune checkpoint inhibitors as conversion therapy for unresectable hepatocellular carcinoma needs more details.

Pubmed   Journal   ReadQx 

Reply: How to count from 0-4 without skipping a number.

Pubmed   Journal   ReadQx 

Reply: Survival benefit of transarterial chemoembolization combined with tyrosine kinase and immune checkpoint inhibitors as conversion therapy for unresectable hepatocellular carcinoma needs more details.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: Are Antispasmodics Truly Ineffective in IBD? Considerations on Nuanced Interpretation and Stratified Analysis.

Pubmed   Journal   ReadQx 

Letter: Are Antispasmodics Truly Ineffective in IBD? Considerations on Nuanced Interpretation and Stratified Analysis. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: Crohn's Disease With Latent Tuberculosis Infection or Intestinal Tuberculosis: Rapid Discrimination by Targeted Next-Generation Sequencing.

Pubmed   Journal   ReadQx 

Letter: Selective FGFR1c/KLB Activation in MASH-A Mechanistic Dilemma?

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

"Reconsidering the relationship between early post-TIPS hepatic encephalopathy and mortality: are we still missing something?"

Pubmed   Journal   ReadQx 

Gastroparesis and Chronic Pancreatitis: Are they Truly Related?

Pubmed   Journal   ReadQx 

Is baseline MASH fibrosis the key determinant for survival after bariatric surgery?

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Comments on the impact of pancreatic endotherapy on quality of life in chronic pancreatitis.

Pubmed   Journal   ReadQx 

Enhancing endoscopic sleeve gastroplasty research: addressing missing data, subgroup variations, and unadjusted confounders.

Pubmed   Journal   ReadQx 

Is the risk of new Barrett's esophagus after sleeve gastrectomy overestimated?

Pubmed   Journal   ReadQx 

Re-evaluating timing and patient selection in endoscopic necrosectomy for walled-off pancreatic necrosis.

Pubmed   Journal   ReadQx 

Gut

Multicentre RCT of a self-assembling haemostatic gel to prevent delayed bleeding following EMR-an underpowered sample size calculation.

Pubmed   Journal   ReadQx 

J Hepatol

Carvedilol is superior to propranolol in preventing first and further decompensation, and mortality in patients with cirrhosis.

Pubmed   Journal   ReadQx